The prevalence of atopy and allergic disease continues to escalate worldwide. Defining
immune mechanisms that suppress the underlying Th2‐driven inflammatory process is …

BACKGROUND: Allergen-specific immunotherapy is the only causative treatment of IgE-
mediated allergic disorders. The most common administration route is subcutaneous, which …

Background Advancement in laboratory techniques in the past decade, coupled with clinical
studies, has afforded a better understanding of the genetic and molecular mechanisms …

LETTERS TO THE EDITOR 991 differences in antibody titers between active/placebo groups
that achieved acceptable statistical significance (P<. 05 after Bonferroni correction) was to …

Background Sustained efficacy over three pollen seasons of pre‐and co‐seasonal treatment
with 300 IR 5‐grass pollen sublingual tablet has been demonstrated in adults with moderate …

Background Plasticity of CD4+ lymphocyte Th17/regulatory T cell (Treg) subsets is involved
in the pathogenesis of chronic airway inflammatory diseases, such as asthma. Reversal of …

IgE antibody-mediated allergies affect more than 25% of the population worldwide. To
investigate therapeutic and preventive effects of passive immunization with allergen-specific …

Specific treatment of allergic diseases has been based mainly on empirically established
traditions until small-scale clinical studies delivered some evidence of the beneficial effect of …

To the Editor: Eosinophilic gastrointestinal disorders (EGIDs) have been associated with IgE
to varying degrees. 1 Patients with allergies to birch pollen can have secondary allergies to …

Background and aims The mechanism of antigen specific immunotherapy (ASIT) remains to
be further understood. The present study aims to investigate the role of ASIT in the …