Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of
which have been extensively studied. Although initially thought to constitute mutually …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Cell death is a fundamental ingredient of life. Thus, not surprisingly more than one form of
cell death exists. Several excellent reviews on various forms of cell death have already been …

The rapid accumulation of knowledge on apoptosis regulation in the 1990s was followed by
the development of several experimental anticancer‐and anti‐ischaemia (stroke or …

Background Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that
contributes to neuronal damage and behavioral impairment. Toll-like receptors (TLRs) are …

This study was conducted to evaluate a possible protective role of apricot in apoptotic cell
death induced by methotrexate (MTX) and renal damage by different histological and …

Mitochondrial dysfunction is commonly believed to be one of the major players in
mechanisms of brain injury. For several decades, pathologic mitochondrial calcium overload …

Inosine is an endogenous purine nucleoside, which is formed during the breakdown of
adenosine. The adenosinergic system was already described as capable of modulating …

NAD+ plays crucial roles in a variety of biological processes including energy metabolism,
aging, and calcium homeostasis. Multiple studies have also shown that NAD+ administration …