Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
Extracts from medicinal plants, many of which have been used for centuries, are increasingly
tested in models of hepatotoxicity. One of the most popular models to evaluate the …
tested in models of hepatotoxicity. One of the most popular models to evaluate the …
Biochemical effects of acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis philippinarum
Acetaminophen (paracetamol) is one of the most used pharmaceutical drugs, due to its
antipyretic and analgesic properties that turn it into a primary choice in varied pathologies …
antipyretic and analgesic properties that turn it into a primary choice in varied pathologies …
Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats
AS Abdel-Azeem, AM Hegazy, KS Ibrahim… - Journal of dietary …, 2013 - Taylor & Francis
Ginger is a remedy known to possess a number of pharmacological properties. This study
investigated efficacy of ginger pretreatment in alleviating acetaminophen-induced acute …
investigated efficacy of ginger pretreatment in alleviating acetaminophen-induced acute …
Protective Effect of Acacia nilotica (L.) against Acetaminophen‐Induced Hepatocellular Damage in Wistar Rats
N Kannan, KM Sakthivel… - Advances in …, 2013 - Wiley Online Library
The potential biological functions of A. nilotica have long been described in traditional
system of medicine. However, the protective effect of A. nilotica on acetaminophen‐induced …
system of medicine. However, the protective effect of A. nilotica on acetaminophen‐induced …
[HTML][HTML] Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress
The aim of the present study was to validate the antioxidant effect of whey protein
hydrolysate (WPH) using a small animal model. Paracetamol is common drug that is safe at …
hydrolysate (WPH) using a small animal model. Paracetamol is common drug that is safe at …
A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk
JG Diaz Ochoa, J Bucher, ARR Péry… - Frontiers in …, 2013 - frontiersin.org
In this study, we focus on a novel multi-scale modeling approach for spatiotemporal
prediction of the distribution of substances and resulting hepatotoxicity by combining cellular …
prediction of the distribution of substances and resulting hepatotoxicity by combining cellular …
[PDF][PDF] Hepatoprotective and antioxidant potential of Withania somnifera against paracetamol-induced liver damage in rats
Objective: The aim of this study was to evaluate the hepatoprotective and antioxidant effects
of Withania somnifera against Paracetamol-induced liver injury in rats. Methods: In the …
of Withania somnifera against Paracetamol-induced liver injury in rats. Methods: In the …
Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice
Y Lv, B Zhang, G Xing, F Wang, Z Hu - Food & function, 2013 - pubs.rsc.org
Naringenin is a natural flavonoid aglycone of naringin that has been reported to have a wide
range of pharmacological properties, such as antioxidant activity and free radical …
range of pharmacological properties, such as antioxidant activity and free radical …
Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity
M Alipour, C Buonocore, A Omri, M Szabo… - Journal of drug …, 2013 - Taylor & Francis
Background: Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in
overdose causes depletion of glutathione (GSH) and hepatotoxicity. N-acetylcysteine (NAC) …
overdose causes depletion of glutathione (GSH) and hepatotoxicity. N-acetylcysteine (NAC) …
Cuscuta chinensis seeds water extraction protecting murine osteoblastic MC3T3-E1 cells against tertiary butyl hydroperoxide induced injury
J Gao, R Li, L Zhang, L Jia, X Ying, D Dou, J Li… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Cuscuta chinensis (C. chinensis) is a well-
known traditional Chinese herb that has been used to treat heart disease, diabetes, liver …
known traditional Chinese herb that has been used to treat heart disease, diabetes, liver …