Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

H Jaeschke, CD Williams, MR McGill, Y Xie… - Food and Chemical …, 2013 - Elsevier
Extracts from medicinal plants, many of which have been used for centuries, are increasingly
tested in models of hepatotoxicity. One of the most popular models to evaluate the …

Biochemical effects of acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis philippinarum

SC Antunes, R Freitas, E Figueira, F Gonçalves… - … Science and Pollution …, 2013 - Springer
Acetaminophen (paracetamol) is one of the most used pharmaceutical drugs, due to its
antipyretic and analgesic properties that turn it into a primary choice in varied pathologies …

Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats

AS Abdel-Azeem, AM Hegazy, KS Ibrahim… - Journal of dietary …, 2013 - Taylor & Francis
Ginger is a remedy known to possess a number of pharmacological properties. This study
investigated efficacy of ginger pretreatment in alleviating acetaminophen-induced acute …

Protective Effect of Acacia nilotica (L.) against Acetaminophen‐Induced Hepatocellular Damage in Wistar Rats

N Kannan, KM Sakthivel… - Advances in …, 2013 - Wiley Online Library
The potential biological functions of A. nilotica have long been described in traditional
system of medicine. However, the protective effect of A. nilotica on acetaminophen‐induced …

[HTML][HTML] Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress

S Athira, B Mann, R Sharma, R Kumar - Journal of dairy Science, 2013 - Elsevier
The aim of the present study was to validate the antioxidant effect of whey protein
hydrolysate (WPH) using a small animal model. Paracetamol is common drug that is safe at …

A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk

JG Diaz Ochoa, J Bucher, ARR Péry… - Frontiers in …, 2013 - frontiersin.org
In this study, we focus on a novel multi-scale modeling approach for spatiotemporal
prediction of the distribution of substances and resulting hepatotoxicity by combining cellular …

[PDF][PDF] Hepatoprotective and antioxidant potential of Withania somnifera against paracetamol-induced liver damage in rats

EP Sabina, M Rasool, M Vedi, D Navaneethan… - Int J Pharm Pharm …, 2013 - academia.edu
Objective: The aim of this study was to evaluate the hepatoprotective and antioxidant effects
of Withania somnifera against Paracetamol-induced liver injury in rats. Methods: In the …

Protective effect of naringenin against acetaminophen-induced acute liver injury in metallothionein (MT)-null mice

Y Lv, B Zhang, G Xing, F Wang, Z Hu - Food & function, 2013 - pubs.rsc.org
Naringenin is a natural flavonoid aglycone of naringin that has been reported to have a wide
range of pharmacological properties, such as antioxidant activity and free radical …

Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity

M Alipour, C Buonocore, A Omri, M Szabo… - Journal of drug …, 2013 - Taylor & Francis
Background: Acetaminophen (APAP) is an antipyretic analgesic drug that when taken in
overdose causes depletion of glutathione (GSH) and hepatotoxicity. N-acetylcysteine (NAC) …

Cuscuta chinensis seeds water extraction protecting murine osteoblastic MC3T3-E1 cells against tertiary butyl hydroperoxide induced injury

J Gao, R Li, L Zhang, L Jia, X Ying, D Dou, J Li… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Cuscuta chinensis (C. chinensis) is a well-
known traditional Chinese herb that has been used to treat heart disease, diabetes, liver …