Highlights•Cryptococcus has an unusual morphological transition in vivo to generate
enlarged titan cells.•Titan cells are greater than 15 μm in diameter, have a thick cell wall …

C ryptococcus is a potentially fatal fungal pathogen and a leading cause of death in
immunocompromised patients. As an opportunistic and facultative intracellular pathogen of …

Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

In fungi, G‐protein coupled receptors (GPCRs) link ligand/nutrient sensing to growth, mating,
developmental/life‐stage activation and pathogenesis. A GPCR was characterized from the …

Cryptococcus is a major fungal pathogen that frequently causes systemic infection in
patients with compromised immunity. Glucose, an important signal molecule and the …

A genome wide analysis of the human fungal pathogen Cryptococcus neoformans var.
grubii has revealed a number of duplications of highly conserved genes involved in …

Highlights•Fungal cell wall composition and structure are influenced by
microenvironments.•In vivo microenvironments remain to be fully defined.•How the complex …

Cryptococcus neoformans is a human fungal pathogen that is also ubiquitous in the
environment. To cause disease inside a human host, C. neoformans must be able to sense …

The Rim101 pathway is a signalling pathway that has been primarily, but not exclusively,
associated with the response to alkaline stress in yeast. The mechanistic basis for activation …