Adaptive humoral immune responses in the airways are mediated by B cells and plasma
cells that express highly evolved and specific receptors and produce immunoglobulins of …

Pancreatic cancer remains one of the most aggressive tumours with a 5-year survival rate of
less than 5%. The dismal prognosis of this tumour entity that is associated with a high …

Purpose: We describe the preclinical pharmacology and antitumor activity of GDC-0068, a
novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical trials for the …

Wide-ranging exploration of analogues of an ATP-competitive pyrrolopyrimidine inhibitor of
Akt led to the discovery of clinical candidate AZD5363, which showed increased potency …

Alternative splicing (AS) is one of the key processes involved in the regulation of gene
expression in eukaryotic cells. AS catalyzes the removal of intronic sequences and the …

Pancreatic cancer–here in particular pancreatic ductal adenocarcinoma (PDAC)–is a still
highly therapy refractory disease. Amongst the mechanisms by which PDAC cells could …

Introduction: Therapeutic gene silencing is a huge promise for the treatment of a variety of
diseases. The translation of this widely used scientific technique toward clinical application …

The deregulation of oncogenic signaling pathways which provide survival advantages to
tumor cells is mediated by multiple cellular networks. Among them, the PI3K-Akt-mTOR axis …

Background The mitogen-activated protein–kinase pathway consisting of the kinases RAF,
MEK, and ERK is central to cell proliferation and survival and is deregulated in more than …

Cholangiocarcinoma (CCA) is a rare, but devastating disease arising from the epithelium of
intrahepatic and extrahepatic bile ducts. There are neither effective systemic therapies nor …