Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

Polycomb-repressive complex 2 (PRC2) comprises specific members of the Polycomb group
of epigenetic modulators. PRC2 catalyzes methylation of histone H3 at Lys 27 (H3K27me3) …

Pluripotent stem cells, like embryonic stem cells (ESCs), have specialized epigenetic
landscapes, which are important for pluripotency maintenance. Transcription factor …

The salamander has the remarkable ability to regenerate its limb after amputation. Cells at
the site of amputation form a blastema and then proliferate and differentiate to regrow the …

The Polycomb‐repressive complex 2 (PRC2) is important for maintenance of stem cell
pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 …

Although changes in chromatin are integral to transcriptional reprogramming during cellular
differentiation, it is currently unclear how chromatin modifications are targeted to specific …

Chromatin-based regulation of herpesviral transcriptional programs is increasingly
appreciated as a mechanism for modulating infection outcomes. Transcriptionally …