Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …

Extracellular purine nucleotides and nucleosides play important roles in the nervous system,
eg, neurotransmission, neuromodulation, chemoattraction and acute inflammation …

P2X receptors are widely distributed in the nervous system, and P2X7 receptors have roles
in neuropathic pain and in the release of cytokines from microglia. They are trimeric …

We have demonstrated that the activation of P2X3 receptor on peripheral afferent neurons is
critical to development of inflammatory hyperalgesia in peripheral tissue, although …

The identity and forms of activating ligands for ion channels are fundamental to their
physiological roles in rapid electrical signaling. P2X receptor channels are ATP-activated …

P2 nucleotide receptors were proposed to consist of two subfamilies based on
pharmacology in 1985, named P2X and P2Y receptors. Later, this was confirmed following …

Prolonged seizures are amongst the most common neurological emergencies. Status
epilepticus is a state of continuous seizures that is life-threatening and prompt termination of …

The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals,
releases ATP in a rhythm, but the role of extracellular ATP in the SCN is still unknown. In this …

The main functions of the respiratory neural network are to produce a coordinated, efficient,
rhythmic motor behavior and maintain homeostatic control over blood oxygen and CO2/pH …

The functions of P2X purinoceptors (P2X1-7) in the nervous system of adults have been
widely studied. However, little is known about their roles during embryonic development …