Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …

Key points• Lung hydration and mucus clearance rates are set by a balance between CFTR‐
mediated Cl− secretion and ENaC‐led Na+ absorption. In CF airways, CFTR is diminished …

A major role of respiratory mucus is to trap inhaled particles, including pathogens and
environmental particulates, to limit body exposure. Despite the tremendous health …

We demonstrate the use of a high resolution form of optical coherence tomography, termed
micro-OCT (μOCT), for investigating the functional microanatomy of airway epithelia. μOCT …

Within this review we will provide a comprehensive understanding in order to improve
existing strategies and to develop new systems to lower the barrier for improving mucosal …

The impaired mucociliary clearance in individuals with Cystic Fibrosis (CF) enables
opportunistic pathogens to colonize CF lungs. Here we show that Rothia mucilaginosa is a …

Cystic fibrosis (CF) is a hereditary disease caused by mutations in the gene encoding the
chloride channel “cystic fibrosis transmembrane conductance regulator”(CFTR). The lack of …

This study was designed to assess the relative importance of Cl− and HCO3− secretion to
mucociliary transport rate (MCT) in ex vivo porcine tracheas. MCT was measured in one …

Insufficient hydration at the airway surface can make mucus adherent and poorly cleared.
Cough, the major mechanism of mucus clearance in disease, is ineffective when mucus is …

Two fundamental mechanisms within alveoli are essential for lung function: regulated fluid
transport and secretion of surfactant. Surfactant is secreted via exocytosis of lamellar bodies …