The air that we breathe contains nearly 21% oxygen, most of which is utilized by
mitochondria during respiration. While we cannot live without it, it was perceived as a bane …

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown
to act on a wide range of histones and non-histone substrates. Numerous studies have …

Influenza virus exploits a number of cellular signaling pathways during the course of its
replication, rendering them potential targets for new therapeutic interventions. Several …

The NF-κB family of transcription factors governs the cellular reaction to a variety of
extracellular signals. Following stimulation, NF-κB activates genes involved in inflammation …

The purpose of this review article is to highlight articles and new research regarding the link
between NF-ĸB and several cancers. This review presents the most up-to-date NF-ĸB …

Multiple myeloma (MM) displays an NFκB activity-related gene expression signature and
about 20% of primary MM samples harbor genetic alterations conducive to intrinsic NFκB …

Positive-strand RNA viruses encompass more than one-third of known virus genera and
include many medically and agriculturally relevant human, animal, and plant pathogens …

Chronic low-grade subclinical inflammation has been increasingly recognized as an
interposer in the endocrine, metabolic and reproductive disturbances that characterize the …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
formation of immune complexes (ICs), which contain a complex mixture of autoantigens …