The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …

A microneedle system has been developed to deliver chemical and biological agents
through the stratum corneum, which is the main barrier to drug delivery. Recently …

Purpose We previously reported the safety and efficacy in animal experiments of
transcutaneous immunization (TCI) using a self-dissolving microneedle patch (MicroHyala; …

The MicroHyala® microneedle (MN) patch was developed to provide a simple, safe, and
effective drug delivery system. In this study, we examined the performance and …

Transcutaneous immunization (TCI) systems that use the skin's immune function are
promising needle-free, easy-to-use, and low-invasive vaccination alternative to …

Seborrheic keratosis is one of the most common skin benign tumors in humans with a high
occurrence rate of 80%–100% in people> 50 years of age; however, its pathogenesis is still …

Introduction: Vaccination, which is the major fundamental prophylaxis against illness and
death from infectious disease, has greatly contributed to the global improvement of human …

Microneedles (MNs) have been developed as medical devices for enhanced and painless
transdermal drug and vaccine delivery. MN-based vaccine application, unlike conventional …

Two types of polymeric micro-needles with 250 and $750 {\mu} m $ lengths were prepared
by a micromolding process. The geometry of dissolving micro-needles with minoxidil was …

微针有助于改善患者的用药依从性, 提高药物的生物利用度. 近年来, 微针在疫苗接种,
蛋白质和多肽给药, DNA 给药, 皮肤美容, 眼科用药, 局部麻醉, 微量取样等领域均有应用 …