Resolution of inflammation: mechanisms and opportunity for drug development
Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …
Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins
D El Kebir, JG Filep - Frontiers in immunology, 2013 - frontiersin.org
Precise control of the neutrophil death program provides a balance between their defense
functions and safe clearance, whereas impaired regulation of neutrophil death is thought to …
functions and safe clearance, whereas impaired regulation of neutrophil death is thought to …
Targeting neutrophil apoptosis for enhancing the resolution of inflammation
D El Kebir, JG Filep - Cells, 2013 - mdpi.com
Resolution of acute inflammation is an active process that requires inhibition of further
leukocyte recruitment and removal of leukocytes from inflamed sites. Emigrated neutrophils …
leukocyte recruitment and removal of leukocytes from inflamed sites. Emigrated neutrophils …
Aberrant neutrophil functions in stable chronic obstructive pulmonary disease: the neutrophil as an immunotherapeutic target
Chronic obstructive pulmonary disease (COPD) is a common, progressive and debilitating
chronic inflammatory condition affecting the lungs, with significant systemic manifestations …
chronic inflammatory condition affecting the lungs, with significant systemic manifestations …
Pharmacological strategies to resolve acute inflammation
Highlights•Inflammation is a physiological process which restores tissue homeostasis.•
Unresolved inflammation can contribute to the pathogenesis of chronic inflammatory …
Unresolved inflammation can contribute to the pathogenesis of chronic inflammatory …
Altered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients
IG Barbosa, CRC Nogueira, NP Rocha… - Journal of psychiatric …, 2013 - Elsevier
Bipolar disorder (BD) is a severe psychiatric disorder of complex physiopathology that has
been associated with a pro-inflammatory state. The aim of the present study was to …
been associated with a pro-inflammatory state. The aim of the present study was to …
Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors
Despite several therapies being currently available to treat inflammatory diseases, new
drugs to treat chronic conditions with less side effects and lower production costs are still …
drugs to treat chronic conditions with less side effects and lower production costs are still …
Sustained oxidative stress causes late acute renal failure via duplex regulation on p38 MAPK and Akt phosphorylation in severely burned rats
Y Feng, Y Liu, L Wang, X Cai, D Wang, K Wu, H Chen… - PloS one, 2013 - journals.plos.org
Background Clinical evidence indicates that late acute renal failure (ARF) predicts high
mortality in severely burned patients but the pathophysiology of late ARF remains undefined …
mortality in severely burned patients but the pathophysiology of late ARF remains undefined …
Investigação do efeito anti-inflamatório dos alcaloides warifteina e metil-warifteina de cissampelos sympodialis EICHL.(menispermaceae) em modelos de inflamação …
HF Costa - 2013 - repositorio.ufpb.br
Root bark infusions of the plant Cissampelos sympodialis Eichl (Menispermaceae) are used
in folk medicine, in Northeast Brazil, for the treatment of diseases of the respiratory and …
in folk medicine, in Northeast Brazil, for the treatment of diseases of the respiratory and …
Neutrophils and Apoptosis
Neutrophils are a fundamental component of the innate immune system and are rapidly
recruited to sites of infection or tissue injury where they protect the host from invading …
recruited to sites of infection or tissue injury where they protect the host from invading …