Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …

Pervasive transcription of eukaryotic genomes stems to a large extent from bidirectional
promoters that synthesize mRNA and divergent noncoding RNA (ncRNA). Here, we show …

Abstract mRNA concentration depends on the balance between transcription and
degradation rates. On both sides of the equilibrium, synthesis and degradation show …

The essential helicase-like protein Sen1 mediates termination of RNA Polymerase II (Pol II)
transcription at snoRNAs and other noncoding RNAs in yeast. A mutation in the Pol II …

Long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression.
In fission yeast, glucose starvation triggers a transcriptional cascade of polyadenylated …

Transcription by RNA polymerase II (Pol II), and all RNA polymerases for that matter, may be
understood as comprising two cycles. The first cycle relates to the basic mechanism of the …

The RNA polymerase II (RNApII) C-terminal domain (CTD)-interacting domain (CID) proteins
are involved in two distinct RNApII termination pathways and recognize different …

Transcription termination in Saccharomyces cerevisiae can be performed by at least two
distinct pathways and is influenced by the phosphorylation status of the carboxy-terminal …

The explosion of high throughput sequencing technologies marked a turn in our way of
understanding the complexity and diversity of the transcriptome, including noncoding …