Risk of breast cancer in Lynch syndrome: a systematic review
Introduction Lynch syndrome is an autosomal dominantly inherited disorder of cancer
susceptibility caused by germline mutations in the DNA mismatch repair (MMR) genes …
susceptibility caused by germline mutations in the DNA mismatch repair (MMR) genes …
Mismatch repair status and clinical outcome in endometrial cancer: a systematic review and meta-analysis
I Diaz-Padilla, N Romero, E Amir, X Matias-Guiu… - Critical reviews in …, 2013 - Elsevier
Background The association between the deficiency in mismatch repair (MMR) genes and
prognosis in women with endometrial cancer is unclear. Here we report a systematic review …
prognosis in women with endometrial cancer is unclear. Here we report a systematic review …
Familial risk-colorectal cancer: ESMO clinical practice guidelines
J Balmaña, F Balaguer, A Cervantes… - Annals of …, 2013 - annalsofoncology.org
Lynch syndrome is the most common hereditary colorectal cancer (CRC) syndrome and it
accounts for∼ 1%-3% of all CRC burden [1]. The syndrome is transmitted with an autosomal …
accounts for∼ 1%-3% of all CRC burden [1]. The syndrome is transmitted with an autosomal …
Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention
KH Lu, M Daniels - Familial cancer, 2013 - Springer
Women with Lynch syndrome have an additional need to address the substantial increased
lifetime risk of endometrial and ovarian cancer. Endometrial or ovarian cancer can be the …
lifetime risk of endometrial and ovarian cancer. Endometrial or ovarian cancer can be the …
Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers
Background Despite regular surveillance colonoscopy, the metachronous colorectal cancer
risk for mismatch repair (MMR) gene mutation carriers after segmental resection for colon …
risk for mismatch repair (MMR) gene mutation carriers after segmental resection for colon …
Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome
Background Lynch syndrome is an autosomal dominantly inherited disorder caused by
germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown …
germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown …
BRAF mutation in sporadic colorectal cancer and Lynch syndrome
A Thiel, M Heinonen, J Kantonen, A Gylling, L Lahtinen… - Virchows Archiv, 2013 - Springer
The aim of the study was to detect mutations of BRAF oncogene in colorectal cancer and to
use this information to identify Lynch syndrome patients. Consecutive cases of primary …
use this information to identify Lynch syndrome patients. Consecutive cases of primary …
Colorectal cancer screening
RW Burt, JA Cannon, DS David, DS Early… - Journal of the National …, 2013 - jnccn.org
Mortality from colorectal cancer can be reduced by early diagnosis and by cancer prevention
through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe …
through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe …
Lynch syndrome-associated neoplasms: a discussion on histopathology and immunohistochemistry
It was a century ago that Warthin, a pathologist, first described the clinical condition now
known as Lynch syndrome. One hundred years later, our understanding of this syndrome …
known as Lynch syndrome. One hundred years later, our understanding of this syndrome …
How do we approach the goal of identifying everybody with Lynch syndrome?
H Hampel, A De La Chapelle - Familial cancer, 2013 - Springer
Lynch syndrome (LS) is the most common inherited cause of colorectal (CRC) and
endometrial cancer. We here define LS as an individual with a germline deleterious …
endometrial cancer. We here define LS as an individual with a germline deleterious …