Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

Investigators have made key advances in rheumatoid arthritis (RA) genetics in the past 10
years. Although genetic studies have had limited influence on clinical practice and drug …

Abstract miRNAs are small non-coding RNA molecules that modulate the expression of
multiple protein-encoding genes at the post-transcriptional level. They have recently been …

MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker
for cancer detection. Our study was designed to identify plasma miRNAs specific for …

Autoimmune diseases are characterized by aberrant immune responses against healthy
cells and tissues, in which a given individual's genetic susceptibilities play a central role; …

abstract Importance Accumulating evidence suggests that IL-17 A has broad pathogenic
roles in multiple autoimmune and immune-mediated inflammatory diseases, including …

Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to
a crosstalk between genetic predisposition and environmental factors. Both variants of …

MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that are made up of
18–25 nucleotides that function in post-transcriptional gene regulation. The expression of …

Epigenetic anomalies are emerging as key pathogenic features of rheumatoid arthritis (RA).
The effect of epigenetics in RA ranges from contributing to complex disease mechanisms to …

An epigenetic change is defined as an alteration in gene expression that does not involve a
change in the DNA sequence. Epigenetic modifications, including DNA methylation, histone …