Thrombosis is the most frequent cause of mortality worldwide and is closely linked to
haemostasis, which is the biological mechanism that stops bleeding after the injury of blood …

Patients with cancer have an increased risk for venous thrombosis. Interestingly, different
cancer types have different rates of thrombosis, with pancreatic cancer having one of the …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

In addition to intracellular organelles, eukaryotic cells contain extracellular organelles which
are released, or shed, into the microenvironment. In practice, most human studies have …

Microparticles are submicron vesicles shed from a variety of cells. Peter Wolf first identified
microparticles in the midst of ongoing blood coagulation research in 1967 as a product of …

Elevated levels of circulating tissue factor‐bearing microparticles (TFMP) have been
associated with an increased risk of developing venous thromboembolism (VTE) in cancer …

Microparticles (MPs) represent a heterogeneous population of submicronic vesicles that are
released in response to cell activation or apoptosis. MPs harbor a large repertoire of cell …

Deep vein thrombosis (DVT) is a common condition characterized by the formation of an
occlusive blood clot in the venous vascular system, potentially complicated by detachment …

The study of blood ex vivo can occur in closed or open systems, with or without flow.
Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate …

Tissue factor (TF) is a transmembrane cofactor that binds and promotes the catalytic activity
of factor (F) VII a. The TF/VII a complex activates FX by limited proteolysis to initiate blood …