Garcinia xanthones as orally active antitumor agents

X Zhang, X Li, H Sun, X Wang, L Zhao… - Journal of medicinal …, 2013 - ACS Publications
Using a newly developed strategy whose key step is the regioselective propargylation of
hydroxyxanthone substrates, 99 structurally diverse Garcinia natural-product-like xanthones …

Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells

X He, X Liu, X Chen, L Bian, W Zhao, J Shen… - … and biophysical research …, 2013 - Elsevier
Glioblastoma multiforme (GBM) is the most common malignant tumor in adults' central
nervous system (CNS). The development of novel anti-cancer agents for GBM is urgent. In …

Polybutylcyanoacrylate nanoparticles for delivering hormone response element-conjugated neurotrophin-3 to the brain of intracerebral hemorrhagic rats

CY Chung, JT Yang, YC Kuo - Biomaterials, 2013 - Elsevier
Hypertensive intracerebral hemorrhage (ICH) is a rapidly evolutional pathology, inducing
necrotic cell death followed by apoptosis, and alters gene expression levels in surrounding …

A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones

KM Elbel, G Guizzunti, MA Theodoraki, J Xu… - Organic & …, 2013 - pubs.rsc.org
Natural products of the caged Garcinia xanthones (CGX) family are characterized by a
unique chemical structure, potent bioactivities and promising pharmacological profiles. We …

Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway

Y Fan, A Peng, S He, X Shao, C Nie… - Journal of …, 2013 - Taylor & Francis
Isogambogenic acid (iso-GNA) is a well-known herbal medicine extracted from Garcinia
hanburyi. Although it is thought to have anti-tumour effects, its function is still unknown. This …

HQS-3, a newly synthesized flavonoid, possesses potent anti-tumor effect in vivo and in vitro

Y Zhou, N Lu, H Zhang, L Wei, L Tao, Q Dai… - European Journal of …, 2013 - Elsevier
HQS-3 is a newly baicalein derivative with a benzene substitution. We investigated the
anticancer effect of HQS-3 in vivo and in vitro. HQS-3 significantly decreased tumor growth …

藤黄化学生物学研究进展

杨靖, 丁黎, 柳文媛, 冯锋, 郭青龙, 尤启冬 - 中国中药杂志, 2013 - cqvip.com
该综述通过对藤黄抗肿瘤药用历史的回顾, 研究现状的总结, 以及笔者课题组近年来的若干发现,
探讨了藤黄化学生物学研究中3 个关键科学问题, 包括藤黄中有哪些化学成分 …

Guttiferone F from the fruit of Garcinia multiflora and its anti-hepatocellular carcinoma activity

LT Lee, HP Tsai, CC Wang, CN Chang, WC Liu… - … & Preventive Nutrition, 2013 - Elsevier
Garcinia multiflora is an evergreen arbor, which belongs to the family of Guttiferae. It grows
mainly at the lower altitudes of the mountains in the Hengchun Peninsula, which is in …

[PDF][PDF] “双镜” 联合治疗急性结肠脾区恶性梗阻1 例

石磊, 陈平, 朱海杭, 赵伟 - 实用临床医药杂志, 2013 - jcmp.yzu.edu.cn
“双镜"联合治疗急性结肠脾区恶性梗阻1例 Page 1 ·202· 实用临床医药杂志 第17卷 Cardiac
Neovascularization After Myocardial Infarction By Recruiting Aphr+Circulating Cells[J].Circ …

藤黄酸诱导非小细胞肺癌细胞凋亡的机制及其与转铁蛋白受体的关系

张洪明, 赵新国, 陈季北 - 实用临床医药杂志, 2013 - jcmp.yzu.edu.cn
目的探讨藤黄酸(GA) 对细胞表面转铁蛋白受体(TFR) 表达差异的SPC-A-1 肺腺癌, SK-MES-1
肺鳞癌细胞的促凋亡作用及其诱导其凋亡的分子机制. 方法采用免疫组化法检测SPC-A-1 及SK …