Only a few years ago it was demonstrated that mammalian DNA contains oxidized forms of 5-
methylcytosine (5mC). The base 5-hydroxymethylcytosine (5hmC) is the most abundant of …

Background DNA methylation (5mC) plays important roles in epigenetic regulation of
genome function. Recently, TET hydroxylases have been found to oxidise 5mC to …

DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-
hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic …

5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …

Abstract The bacterial SOS response is an elaborate program for DNA repair, cell cycle
regulation and adaptive mutagenesis under stress conditions. Using sensitive sequence …

The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil,
thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5 …

A sensitive, homogeneous fluorescence assay for detection of thymine DNA glycosylase
activity based on exonuclease-mediated amplification - Chemical Communications (RSC …

The mammalian thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5caC) when
paired with a guanine in a CpG sequence, in addition to mismatched bases. Here we …

The Zfp57 gene encodes a KRAB (Krüppel-associated box) domain-containing C2H2 zinc
finger transcription factor that is expressed in early development. Zfp57 protein recognizes …

Functions of the nervous system are accompanied at the cellular level by changes in gene
expression, regulated by transcription factors and epigenetic mechanisms, such as histone …