Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells
Glucagon-like peptide-1 receptor (GLP-1R) plays a major role in promoting glucose-
stimulated insulin secretion in pancreatic β-cells. In the present study, we synthesized a …
stimulated insulin secretion in pancreatic β-cells. In the present study, we synthesized a …
[HTML][HTML] A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1 …
Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and
glucagon bind to related members of the same receptor superfamily and exert important …
glucagon bind to related members of the same receptor superfamily and exert important …
Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta‐cells, isolated pancreatic islets and mice
AM McKillop, BM Moran… - British journal of …, 2013 - Wiley Online Library
Background and Purpose G‐protein coupled receptor (GPR) 55 is a novel lipid sensing
receptor activated by both cannabinoid endogenous ligands (endocannabinoids) and other …
receptor activated by both cannabinoid endogenous ligands (endocannabinoids) and other …
A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties
Oxyntomodulin (Oxm) is a 37-amino acid peptide linked to alleviation of obesity-diabetes
through a dual mode of action mediated at both glucagon and GLP-1 receptors. GIP is the …
through a dual mode of action mediated at both glucagon and GLP-1 receptors. GIP is the …
[HTML][HTML] A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice
Aims/hypothesis We designed a chemically modified, enzyme-resistant peptide with triple-
acting properties based on human glucagon with amino acid substitutions aligned to …
acting properties based on human glucagon with amino acid substitutions aligned to …
miR-25 and miR-92a regulate insulin I biosynthesis in rats
D Setyowati Karolina, S Sepramaniam, HZ Tan… - RNA biology, 2013 - Taylor & Francis
The 3′ UTR of insulin has been identified as a critical region that confers mRNA stability,
which is crucial for promoting transcription in response to glucose challenge. miRNAs are …
which is crucial for promoting transcription in response to glucose challenge. miRNAs are …
Role of proteins in insulin secretion and glycemic control
V Ranawana, B Kaur - Advances in food and nutrition research, 2013 - Elsevier
Dietary proteins are essential for the life of all animals and humans at all stages of the life
cycle. They serve many structural and biochemical functions and have significant effects on …
cycle. They serve many structural and biochemical functions and have significant effects on …
A novel acylated form of (d-Ala2) GIP with improved antidiabetic potential, lacking effect on body fat stores
BACKGROUND: Rapid enzymatic degradation of the incretin hormone, glucose-dependent
insulinotropic polypeptide (GIP), limits therapeutic use of the native peptide for diabetes …
insulinotropic polypeptide (GIP), limits therapeutic use of the native peptide for diabetes …
[HTML][HTML] High glucose activates the alternative ACE2/Ang‑(1‑7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β‑cells
C Härdtner, C Mörke, R Walther… - International …, 2013 - spandidos-publications.com
The activation of the classical angiotensin (Ang)‑converting enzyme (ACE)/Ang II/Ang II type
1 receptor (AT1R) axis of the renin‑angiotensin system (RAS) has been associated with islet …
1 receptor (AT1R) axis of the renin‑angiotensin system (RAS) has been associated with islet …
Metabolomic analysis of pancreatic beta cells following exposure to high glucose
BACKGROUND: Chronic exposure to hyperglycaemic conditions has been shown to have
detrimental effects on beta cell function. The resulting glucotoxicity is a contributing factor to …
detrimental effects on beta cell function. The resulting glucotoxicity is a contributing factor to …