Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis
Y Wang, Y Shang - Experimental cell research, 2013 - Elsevier
Epithelial–mesenchymal transition (EMT) is vital for morphogenesis during embryonic
development and is also critical for the conversion of early stage tumors into invasive …
development and is also critical for the conversion of early stage tumors into invasive …
[HTML][HTML] Epigenetic landscape of Parkinson's disease: emerging role in disease mechanisms and therapeutic modalities
NA Kaidery, S Tarannum, B Thomas - Neurotherapeutics, 2013 - Elsevier
Parkinson's disease (PD) is a complex multifactorial disorder marked by extensive system-
wide pathology, including a substantial loss of nigrostriatal dopaminergic neurons. The …
wide pathology, including a substantial loss of nigrostriatal dopaminergic neurons. The …
PHYTOCHROME INTERACTING FACTOR3 associates with the histone deacetylase HDA15 in repression of chlorophyll biosynthesis and photosynthesis in etiolated …
X Liu, CY Chen, KC Wang, M Luo, R Tai, L Yuan… - The Plant …, 2013 - academic.oup.com
Abstract PHYTOCHROME INTERACTING FACTOR3 (PIF3) is a key basic helix-loop-helix
transcription factor of Arabidopsis thaliana that negatively regulates light responses …
transcription factor of Arabidopsis thaliana that negatively regulates light responses …
Histone Acetyltransferase PCAF Is Required for Hedgehog–Gli-Dependent Transcription and Cancer Cell Proliferation
M Malatesta, C Steinhauer, F Mohammad, DP Pandey… - Cancer research, 2013 - AACR
Abstract The Hedgehog (Hh) signaling pathway plays an important role in embryonic
patterning and development of many tissues and organs as well as in maintaining and …
patterning and development of many tissues and organs as well as in maintaining and …
Epigenetics and aging
Over the past two decades, a growing interest on the research of the biological basis of
human longevity has emerged, in order to clarify the intricacy of biological and …
human longevity has emerged, in order to clarify the intricacy of biological and …
Epigenetic regulation of inducible gene expression in the immune system
PS Lim, J Li, AF Holloway, S Rao - Immunology, 2013 - Wiley Online Library
T cells are exquisitely poised to respond rapidly to pathogens and have proved an
instructive model for exploring the regulation of inducible genes. Individual genes respond …
instructive model for exploring the regulation of inducible genes. Individual genes respond …
Histone deacetylase inhibitors: an attractive strategy for cancer therapy
J Li, G Li, W Xu - Current medicinal chemistry, 2013 - ingentaconnect.com
Histone deacetylases are able to catalyze the hydrolysis of N-acetyl lysine residues of
histones which package chromosomal DNA. Therefore they play an important role in …
histones which package chromosomal DNA. Therefore they play an important role in …
Sirtuins as emerging anti-parasitic targets
W Zheng - European journal of medicinal chemistry, 2013 - Elsevier
Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of NAD+-dependent
protein Nε-acetyl-lysine (AcK) deacetylases. Sirtuins are also evolutionarily conserved …
protein Nε-acetyl-lysine (AcK) deacetylases. Sirtuins are also evolutionarily conserved …
Peptide based macrocycles: selective histone deacetylase inhibitors with antiproliferative activity
Histone deacetylase inhibitors (HDACi) have been enthusiastically investigated as a novel
generation of chemotherapeutics for cancers usually called as epigenetic therapeutics …
generation of chemotherapeutics for cancers usually called as epigenetic therapeutics …
Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics
Rtt109 is a fungal-specific histone acetyltransferase (HAT) that associates with either Vps75
or Asf1 to acetylate histone H3. Recent biochemical and structural studies suggest that site …
or Asf1 to acetylate histone H3. Recent biochemical and structural studies suggest that site …