A novel and efficient synthesis of pyrazolo [3, 4-d] pyrimidine derivatives and the study of their anti-bacterial activity
S Rostamizadeh, M Nojavan, R Aryan… - Chinese Chemical …, 2013 - Elsevier
In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized
through a one-pot, three-component reaction of an aldehyde, malononitrile and …
through a one-pot, three-component reaction of an aldehyde, malononitrile and …
Enhancement of rhubarb extract solubility and bioactivity by 2-hydroxypropyl-β-cyclodextrin
Rhubarb is a traditional Chinese medicinal herb, and the ethanolic extract of rhubarb
consists of active anthraquinones, which are hydrophobic and have antiproliferative effects …
consists of active anthraquinones, which are hydrophobic and have antiproliferative effects …
Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant
Starting from our in-house library of pyrazolo [3, 4-d] pyrimidines, a cross-docking simulation
was conducted on Bcr-Abl T315I mutant. Among the selected compounds (2a–e), the 4 …
was conducted on Bcr-Abl T315I mutant. Among the selected compounds (2a–e), the 4 …
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
G Vignaroli, C Zamperini, E Dreassi… - ACS Medicinal …, 2013 - ACS Publications
Design and synthesis of prodrugs of promising drug candidates represents a valid strategy
to overcome the lack of favorable ADME properties, in particular aqueous solubility and …
to overcome the lack of favorable ADME properties, in particular aqueous solubility and …
A Facile Synthesis of New Pyrazolo[3,4‐d]pyrimidine Derivatives via a One‐Pot Four‐Component Reaction with Sodium Acetate Supported on Basic Alumina as …
S Rostamizadeh, M Nojavan, R Aryan… - Helvetica Chimica …, 2013 - Wiley Online Library
An efficient one‐pot procedure for the synthesis of 3‐amino‐6‐aryl‐2‐phenylpyrazolo [3, 4‐
d] pyrimidine derivatives, through the reaction of aldehydes, malononitrile, benzamidine …
d] pyrimidine derivatives, through the reaction of aldehydes, malononitrile, benzamidine …
[PDF][PDF] Utility of 6-aryl-5-Cyano-2-thiouracil derivative as a precursor for the synthesis of some new pyrimidines
E Abdelghani, SA Said, MG Assy, AAM Hamid - Am. J. Org. Chem, 2013 - academia.edu
Abstract Reactions of 6-aryl-5-cyano-2-thiouracil derivatives 1a, b with a variety of reagents
leads to the synthesis of some new pyrimidines and condensed pyrimidines. The …
leads to the synthesis of some new pyrimidines and condensed pyrimidines. The …
An unexpected synthesis of novel pyrazolo [3, 4-d] pyrimidine derivatives using 6-aminopyrimidine-5-carbonitrile derivatives as reactant
S Rostamizadeh, M Nojavan - 2013 - sid.ir
Abstract PYRAZOLO [3, 4-D] PYRIMIDINES HAVE ATTRACTED CONSIDERABLE
INTEREST DUE TO THEIR REMARKABLE PHARMACOLOGICAL PROPERTIES SUCH AS …
INTEREST DUE TO THEIR REMARKABLE PHARMACOLOGICAL PROPERTIES SUCH AS …
Synthesis of new pyrazolo [3, 4d] pyrimidine derivatives via a one-pot four-component reaction
S Rostamizadeh, M Nojavan - 2013 - sid.ir
Abstract FUSED PYRIMIDINE DERIVATIVES HAVE SHOWN DIVERSE BIOLOGICAL
ACTIVITIES, AMONG THEM, PYRAZOLO [3, 4-D] PYRIMIDINES AS PURINE ANALOGS …
ACTIVITIES, AMONG THEM, PYRAZOLO [3, 4-D] PYRIMIDINES AS PURINE ANALOGS …
[引用][C] Synthesis, antimicrobial and cytotoxic activity of novel 4-phenoxy and 4-(substitutedamino) pyrazolo [3, 4-d] pyrimidine derivatives
MK Abd El Hameid, HB El-Nassan, KO Ahmed - 2013