Synucleinopathies include Parkinson's disease, dementia with Lewy bodies, Lewy body
variant of Alzheimer's disease and multiple system atrophy, among the most relevant …

Neurodegenerative diseases are capturing the world's attention as being the next set of
diseases we must tackle collectively. Not only are the patients experiencing gradual …

Many proteins associated with neurodegenerative diseases have poorly defined or
unknown functions. α-Synuclein is one such protein which is associated with a range of …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by peptide
and protein misfolding and aggregation, in part due to the presence of excess metal ions …

Aggregation of the 140-amino acid protein α-synuclein (α-syn) is linked to the development
of Parkinson's disease (PD). α-Syn is a copper binding protein with potential function as a …

The aggregation of α-synuclein is thought to play a role in the death of dopamine neurons in
Parkinson's disease (PD). Alpha-synuclein transitions itself through an aggregation pathway …

In a recent study we discovered that a ring-fused 2-pyridone compound triggered
fibrillization of a key protein in Parkinson's disease, α-synuclein. To reveal how variations in …

Molecular modeling techniques play a relevant role in drug design providing detailed
information at atomistic level on the structural, dynamical, mechanistic and electronic …

Alpha-synuclein is a cytosolic protein associated with a range of diseases including
Parkinson's disease. In these diseases alpha-synuclein aggregates and this is believed to …

Truncated and mutated amyloid‐β (Aβ) peptides are models for systematic study—in
homogeneous preparations—of the molecular origins of metal ion effects on Aβ aggregation …