Functions of the skin microbiota in health and disease

JA Sanford, RL Gallo - Seminars in immunology, 2013 - Elsevier
The skin, the human body's largest organ, is home to a diverse and complex variety of innate
and adaptive immune functions. Despite this potent immune system present at the …

Compartmentalized and systemic control of tissue immunity by commensals

Y Belkaid, S Naik - Nature immunology, 2013 - nature.com
The body is composed of various tissue microenvironments with finely tuned local
immunosurveillance systems, many of which are in close apposition with distinct commensal …

[HTML][HTML] Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States

A Lin, EM Bik, EK Costello, L Dethlefsen, R Haque… - PloS one, 2013 - journals.plos.org
Background Our current understanding of the composition and stability of the human distal
gut microbiota is based largely on studies of infants and adults living in developed countries …

The neuropathic diabetic foot ulcer microbiome is associated with clinical factors

SE Gardner, SL Hillis, K Heilmann, JA Segre… - Diabetes, 2013 - Am Diabetes Assoc
Nonhealing diabetic foot ulcers (DFUs) are a common and costly complication of diabetes.
Microbial burden, or “bioburden,” is believed to underlie delayed healing, although little is …

What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome

TC Scharschmidt, MA Fischbach - Drug Discovery Today: Disease …, 2013 - Elsevier
Our skin is home to a rich community of microorganisms. Recent advances in sequencing
technology have allowed more accurate enumeration of these human-associated microbiota …

Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections

H Sikorska, W Smoragiewicz - International journal of antimicrobial agents, 2013 - Elsevier
Meticillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant micro-organism
and is the principal nosocomial pathogen worldwide. Following initial in vitro experiments …

The microbiome in wound repair and tissue fibrosis

BS Scales, GB Huffnagle - The Journal of pathology, 2013 - Wiley Online Library
Bacterial colonization occurs in all wounds, chronic or acute, and the break in epithelium
integrity that defines a wound impairs the forces that shape and constrain the microbiome at …

Complement modulates the cutaneous microbiome and inflammatory milieu

C Chehoud, S Rafail, AS Tyldsley… - Proceedings of the …, 2013 - National Acad Sciences
The skin is colonized by a plethora of microbes that include commensals and potential
pathogens, but it is currently unknown how cutaneous host immune mechanisms influence …

The skin surface as antimicrobial barrier: present concepts and future outlooks

J Harder, JM Schröder, R Gläser - Experimental dermatology, 2013 - Wiley Online Library
Human skin protects the body as an outer barrier from various environmental threats and
has to deal with an immense quantity of microbes comprising members of the own …

Enhanced lymph vessel density, remodeling, and inflammation are reflected by gene expression signatures in dermal lymphatic endothelial cells in type 2 diabetes

M Haemmerle, T Keller, G Egger, H Schachner… - Diabetes, 2013 - Am Diabetes Assoc
Type 2 diabetes is associated with microvascular damage that causes frequent infections in
the skin and chronic ulcers as a result of impaired wound healing. To trace the pathological …