Exome sequencing offers the potential to study the population-genomic variables that
underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of …

Determining the genetic architecture of liability for complex neuropsychiatric disorders like
autism spectrum disorders and schizophrenia poses a tremendous challenge for …

Background Genome-wide association studies have identified thousands of SNP variants
associated with hundreds of phenotypes. For most associations the causal variants and the …

Objective Stress is implicated as a risk factor for numerous illnesses in humans, putatively in
part mediated by biological responses to stress, such as elevated cortisol concentrations …

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide.
Previous genome-wide association (GWA) studies have identified several common variants …

Serum concentration of total cholesterol (TC) is a complex trait, for which genomewide
association studies discovered common genetic variants explaining about 30% of TC …

Exome sequencing offers the potential to study the population-genomic variables that
underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of …

Understanding the fitness effects of inbreeding is a crucial and long standing goal in
conservation and evolutionary biology. Many studies measure individual inbreeding (F, the …