Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Postmenopausal osteoporosis is the most common bone disease, associated with low bone
mineral density (BMD) and pathological fractures which lead to significant morbidity. It is …

Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling
(canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the …

Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …

Objective Lumbar disc degeneration (LDD) is an important cause of low back pain, which is
a common and costly problem. LDD is characterised by disc space narrowing and …

Most previous genetic epidemiology studies within the field of osteoporosis have focused on
the genetics of the complex trait areal bone mineral density (aBMD), not being able to …

Natural variation in human skin pigmentation is primarily due to genetic causes rooted in
recent evolutionary history. Genetic variants associated with human skin pigmentation …

Previous genome‐wide association studies (GWAS) have identified common variants in
genes associated with variation in bone mineral density (BMD), although most have been …

Background Progression of joint destruction in rheumatoid arthritis (RA) is partly heritable;
knowledge of genetic factors may increase our understanding of the mechanisms underlying …

BACKGROUND: Genome-wide association studies have established 11 genes for late-
onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition …