Receiving both portal vein blood and arterial blood, the liver is an important and critical
component in the defense against blood-borne infection. To accomplish this role, the liver …

The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Background & Aims Myeloid derived suppressor cells (MDSCs) are a heterogeneous
population of cells associated with the suppression of immunity. However, little is known …

Myeloid-derived suppressor cells (MDSCs) play an important role in the regulation of the
immune response. MDSC expansion occurs in many circumstances, including cancer …

Hepatocellular carcinoma (HCC) is the most common liver malignancy, representing the
third and fifth leading cause of death from cancer worldwide in men and women …

Because of its unique blood supply, the liver maintains a special local immune tolerogenic
microenvironment. Moreover, the liver can impart this immune tolerogenic effect on other …

Background The liver is an immunologic privileged organ; liver allografts are accepted
across major histocompatibility complex barriers in many species. However, hepatocyte …

Hepatic stellate cells (HSCs) have immunosuppressive capabilities and contribute to the
occurrence and development of hepatocellular carcinoma (HCC). Thus, activated HSCs may …

With their location in the perisinusoidal space of Disse, hepatic stellate cells (HSCs)
communicate with all of the liver cell types both by physical association (cell body as well as …

Hepatic stellate cells (HSCs) have been demonstrated to have immunoinhibitory activity.
The aim of this study was to investigate the role of HSCs in the development of …