WNT signaling in bone homeostasis and disease: from human mutations to treatments
R Baron, M Kneissel - Nature medicine, 2013 - nature.com
Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
[HTML][HTML] Bone composition: relationship to bone fragility and antiosteoporotic drug effects
AL Boskey - BoneKEy reports, 2013 - ncbi.nlm.nih.gov
The composition of a bone can be described in terms of the mineral phase, hydroxyapatite,
the organic phase, which consists of collagen type I, noncollagenous proteins, other …
the organic phase, which consists of collagen type I, noncollagenous proteins, other …
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus
Central corneal thickness (CCT) is associated with eye conditions including keratoconus
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
and glaucoma. We performed a meta-analysis on> 20,000 individuals in European and …
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
E Canalis - Nature Reviews Endocrinology, 2013 - nature.com
Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
U Styrkarsdottir, G Thorleifsson, P Sulem… - Nature, 2013 - nature.com
Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …
A comprehensive overview of skeletal phenotypes associated with alterations in Wnt/β-catenin signaling in humans and mice
KA Maupin, CJ Droscha, BO Williams - Bone Research, 2013 - nature.com
The Wnt signaling pathway plays key roles in differentiation and development and
alterations in this signaling pathway are causally associated with numerous human …
alterations in this signaling pathway are causally associated with numerous human …
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Most previous genetic epidemiology studies within the field of osteoporosis have focused on
the genetics of the complex trait areal bone mineral density (aBMD), not being able to …
the genetics of the complex trait areal bone mineral density (aBMD), not being able to …
Meta‐analysis of genome‐wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women
Previous genome‐wide association studies (GWAS) have identified common variants in
genes associated with variation in bone mineral density (BMD), although most have been …
genes associated with variation in bone mineral density (BMD), although most have been …
Shaping development through mechanical strain: the transcriptional basis of diet‐induced phenotypic plasticity in a cichlid fish
Adaptive phenotypic plasticity, the ability of an organism to change its phenotype to match
local environments, is increasingly recognized for its contribution to evolution. However, few …
local environments, is increasingly recognized for its contribution to evolution. However, few …
Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs
MD Cantley, DR Haynes - Inflammopharmacology, 2013 - Springer
Inhibition of histone deacetylases (HDAC) is emerging as a novel approach to treat a variety
of diseases. Recently, broad acting inhibitors of HDAC have been shown to have anti …
of diseases. Recently, broad acting inhibitors of HDAC have been shown to have anti …