Ionizing radiation produces its deleterious biologic effects by both direct (DNA strand
breaks) and indirect processes (formation of free oxygen radicals). Mitotically active cells are …

As the number of cancer survivors continues to grow, research investigating the factors that
affect cancer outcomes, such as disease recurrence, risk of second malignant neoplasms …

The purpose of this study is to determine the incidence, clinical characteristics and risk
factors of postradiation pelvic insufficiency fracture (PIF) in women with uterine cervical …

Radiation therapy is a common treatment regimen for cancer patients. However, its adverse
effects on the neighboring bone could lead to fractures with a great impact on quality of life …

Background Estimating the incidence of medical conditions using claims data often requires
constructing a prevalence period that predates an event of interest, for instance the …

Purpose: Little is known regarding radiation effects on adult articular (joint) cartilage, though
joint damage has been reported following cancer treatment or occupational exposures. The …

Radiation therapy for soft tissue sarcomas and metastatic disease can adversely affect bone,
leading to late-onset fragility fractures. Adjunct administration of bisphosphonates has been …

Ionizing radiation therapy is a crucial treatment for cancer, but can damage surrounding
normal tissues. Damage to articular cartilage leading to arthropathy can occur at irradiated …

Purpose To prospectively investigate the changes in bone mineral density (BMD) after pelvic
radiation therapy in patients with uterine cervical cancer. Methods and Materials Of 52 …

Our purpose was to characterize changes in bone remodeling associated with localized
radiation that models therapeutic cancer treatment in ovary-intact (I) and ovariectomized …