Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases
T Vanessa Fiorentino, A Prioletta… - Current …, 2013 - ingentaconnect.com
Diabetes mellitus is associated to an increased risk of cardiovascular diseases.
Hyperglycemia is an important factor in cardiovascular damage, working through different …
Hyperglycemia is an important factor in cardiovascular damage, working through different …
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
[HTML][HTML] Free radical biology for medicine: learning from nonalcoholic fatty liver disease
G Serviddio, F Bellanti, G Vendemiale - Free Radical Biology and Medicine, 2013 - Elsevier
Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …
contribute to cellular proliferation, senescence, and survival by acting as signaling …
Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding
In pharmacology, it is crucial to understand the complex biological responses that drugs
elicit in the human organism and how well they can be inferred from model organisms. We …
elicit in the human organism and how well they can be inferred from model organisms. We …
Lipid biology of breast cancer
J Baumann, C Sevinsky, DS Conklin - … (BBA)-Molecular and Cell Biology of …, 2013 - Elsevier
Alterations in lipid metabolism have been reported in many types of cancer. Lipids have
been implicated in the regulation of proliferation, differentiation, apoptosis, inflammation …
been implicated in the regulation of proliferation, differentiation, apoptosis, inflammation …
Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis
Endoplasmic reticulum (ER) stress is a regulatory mechanism that allows cells to adapt to a
series of metabolic, redox, and other environmental changes. The role of ER stress was first …
series of metabolic, redox, and other environmental changes. The role of ER stress was first …
hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress
A growing amount of evidence suggests the involvement of ER (endoplasmic reticulum)
stress in lipid metabolism and in the development of some liver diseases such as steatosis …
stress in lipid metabolism and in the development of some liver diseases such as steatosis …
ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity
JX Rong, C Blachford, JE Feig, I Bander… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Acyl-CoA: cholesterol acyltransferase (ACAT) converts cholesterol to cholesteryl
esters in plaque foam cells. Complete deficiency of macrophage ACAT has been shown to …
esters in plaque foam cells. Complete deficiency of macrophage ACAT has been shown to …
Flaviviral regulation of the unfolded protein response: can stress be beneficial?
RL Ambrose, JM Mackenzie - Future Virology, 2013 - Taylor & Francis
Members of the Flaviviridae family remain some of the most significant human viral
pathogens, with few vaccines or antivirals commercially available for therapeutic use. Thus …
pathogens, with few vaccines or antivirals commercially available for therapeutic use. Thus …