Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and …

R Domitrović, O Cvijanović, E Pernjak-Pugel… - Food and chemical …, 2013 - Elsevier
The aim of this study was to investigate the therapeutic activity of isoquinoline alkaloid
berberine against cisplatin (CP)-induced nephrotoxicity in mice. Berberine was administered …

Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice

R Domitrović, M Škoda, VV Marchesi… - Food and chemical …, 2013 - Elsevier
The aim of this study was to investigate the therapeutic potential of rosmarinic acid (RA), a
natural phenolic, in the treatment of acute liver toxicity. RA at 10, 25 and 50mg/kg was …

Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation

JS Teodoro, FV Duarte, AP Gomes, AT Varela… - Mitochondrion, 2013 - Elsevier
Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of
liver and thus hepatic mitochondria in whole-body metabolism, berberine effects on hepatic …

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

J Zhang, H Cao, B Zhang, H Cao, X Xu… - Journal of cellular …, 2013 - Wiley Online Library
As a traditional anti‐inflammatory C hinese herbal medicine, Alkaloid berberine has been
recently reported to exhibit anti‐tumour effects against a wide spectrum of cancer. However …

[HTML][HTML] Aqueous Extract of the Edible Gracilaria tenuistipitata Inhibits Hepatitis C Viral Replication via Cyclooxygenase-2 Suppression and Reduces Virus-Induced …

KJ Chen, CK Tseng, FR Chang, JI Yang, CC Yeh… - PloS one, 2013 - journals.plos.org
Hepatitis C virus (HCV) is an important human pathogen leading to hepatocellular
carcinoma. Using an in vitro cell-based HCV replicon and JFH-1 infection system, we …

Resolution of Liver Fibrosis by Isoquinoline Alkaloid Berberine in CCl4-Intoxicated Mice Is Mediated by Suppression of Oxidative Stress and Upregulation of MMP-2 …

R Domitrović, H Jakovac, VV Marchesi… - Journal of medicinal …, 2013 - liebertpub.com
Liver fibrosis is the result of chronic liver injury, and it represents a widespread medical
problem. The aim of this study is to investigate the antifibrotic activity of isoquinoline alkaloid …

A metabolic profiling analysis of the acute hepatotoxicity and nephrotoxicity of Zhusha Anshen Wan compared with cinnabar in rats using 1H NMR spectroscopy

H Wang, J Bai, G Chen, W Li, R Xiang, G Su… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Zhusha Anshen Wan (ZSASW), a traditional
Chinese medicine (TCM) prescription, composed of cinnabar (cinnabaris), Coptidis …

Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential …

A Paul, J Das, S Das, A Samadder… - Environmental …, 2013 - Elsevier
This study evaluates the possible protective potentials of chelidonine and its poly lactide-co-
glycolide (PLGA) encapsulated nano-form against cadmium chloride (CdCl 2) induced …

Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails

K Sahin, C Orhan, M Tuzcu, MH Borawska… - British Journal of …, 2013 - cambridge.org
To evaluate the action mode of Berberis vulgaris root extract in the alleviation of oxidative
stress, female Japanese quails (n 180, aged 5 weeks) were reared, either at 22° C for 24 h/d …

The selective 5-LOX inhibitor 11-keto-β-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory …

SM Elshazly, DM Abd El Motteleb… - … Schmiedeberg's archives of …, 2013 - Springer
Myocardial ischemia induces 5-lipoxygenase (LOX) translocation and leukotriene
production in the heart. Leukotrienes increase inflammatory responses aggravating, thereby …