Single enzyme studies reveal the existence of discrete functional states for monomeric enzymes and how they are “selected” upon allosteric regulation
NS Hatzakis, L Wei, SK Jorgensen, AH Kunding… - Biophysical …, 2013 - cell.com
Allosteric regulation of enzymatic activity forms the basis for controlling a plethora of vital
cellular processes. While the mechanism underlying regulation of multimeric enzymes is …
cellular processes. While the mechanism underlying regulation of multimeric enzymes is …
A “bridge-like” structure responsible for the substrate selectivity of mono-and diacylglycerol lipase from Aspergillus oryzae
Lipase from Aspergillus oryzae (AOL) was experimentally identified to be strictly specific for
mono-and diacylglycerol, but not triacylglycerol, whose substrate selectivity was …
mono-and diacylglycerol, but not triacylglycerol, whose substrate selectivity was …
Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: a candidate for enzyme replacement therapy
H Wang, J Hagedorn, A Svendsen, K Borch… - Biophysical …, 2013 - Elsevier
Lipases with high kinetic stability and enzymatic efficiency in the human gastro-intestinal
tract may help against exocrine pancreatic insufficiency. Here we mimic gastric conditions to …
tract may help against exocrine pancreatic insufficiency. Here we mimic gastric conditions to …