Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

Segundo a Organização Mundial de Saúde (OMS), a Doença Cardiovascular (DCV) é a
principal causa de morte no mundo, perfazendo 30% das mortes globais1, taxa …

Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil)
reduce the risks of macular degeneration and cancers, but the mechanisms by which these …

Fullerenes are carbon spheres presently being pursued globally for a wide range of
applications in nanomedicine. These molecules have unique electronic properties that make …

Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial
effects in cardiovascular, inflammatory, and metabolic diseases in murine models. Mice with …

Bioactive lipid mediators play crucial roles in promoting the induction and resolution of
inflammation. Eicosanoids and other related unsaturated fatty acids have long been known …

Arachidonic acid (ARA) undergoes enzyme-mediated oxidative metabolism, resulting in the
formation of a number of biologically active metabolites. For over a century, these …

Soluble epoxide hydrolase (sEH, EPHX2) metabolizes eicosanoid epoxides, including
epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids …

In response to endothelial cell activation, arachidonic acid can be converted by cytochrome
P450 (CYP) epoxygenases to epoxyeicosatrienoic acids (EETs), which have potent …