Background Between 10% to 18% of people undergoing cholecystectomy for gallstones
have common bile duct stones. Treatment of the bile duct stones can be conducted as open …

Background Gallstones are present in about 10% to 15% of the adult western population.
Between 1% and 4% of these adults become symptomatic in a year (the majority due to …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

The CONSORT (Consolidated Standards of Reporting Trials) Statement aims to improve the
reporting of randomized controlled trials (RCTs); however, it lacks guidance on the reporting …

The protocol is an important document that details the background, methods, ethical
considerations, and administration of a clinical trial. 1 The information contained in the …

Background Xerostomia is the subjective sensation of dry mouth. Common causes of
xerostomia include adverse effects of many commonly prescribed medications, disease (eg …

Unpublished and misreported studies make it difficult to determine the true value of a
treatment. Peter Doshi and colleagues call for sponsors and investigators of abandoned …

Background Laparoscopic cholecystectomy is used to manage symptomatic gallstones.
There is considerable controversy regarding whether it should be done as day‐surgery or as …

Background The management of people at high risk of perioperative death due to their
general condition (high‐risk surgical patients) with acute calculous cholecystitis is …

Background Periodontal disease and dental caries are highly prevalent oral diseases that
can lead to pain and discomfort, oral hygiene and aesthetic problems, and eventually tooth …