The theory of developmental programming suggests that diseases such as the metabolic
syndrome may be 'programmed'by exposure to adverse stimuli during early development …

Precocious puberty is a common problem affecting up to 29 per 100 000 girls per year. The
earliest identified neuroendocrine change in early puberty thus far is increased kisspeptin …

Background The onset of puberty is first detected as an increase in pulsatile secretion of
gonadotropin-releasing hormone (GnRH). Early activation of the hypothalamic–pituitary …

Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand,
kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary …

Puberty is initiated by gonadotropin-releasing hormone from the hypothalamus followed by
a complex sequence of endocrine changes and is regulated by both genetic and …

Complex mechanisms exist in the human to defend against adverse effects of negative
energy balance. These include alterations of hormone secretion affecting the growth …

Kisspeptins are a family of overlapping neuropeptides encoded by the Kiss1 gene that
regulate the mammalian reproductive axis by a central action in the hypothalamus to …

Background Kisspeptin is a novel hypothalamic peptide which stimulates endogenous
gonadotrophin releasing hormone (GnRH) secretion. A single subcutaneous bolus injection …

The kisspeptin system is now accepted as a key regulator of vertebrate reproductive
function, particularly the onset of puberty. In teleosts, the stimulatory effect of exogenous …

We aimed to describe the functional changes of Sertoli cells, based on the measurement of
serum anti‐Müllerian hormone (AMH) and inhibin B during treatment with GnRHa and after …