Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …

Azoospermia due to obstructive and non-obstructive mechanisms is a common
manifestation of male infertility accounting for 10-15% of such cases. Known genetic factors …

Disorders of sex development (DSDs) are congenital conditions with discrepancies between
the chromosomal, gonadal, and phenotypic sex of the individual. Such disorders have …

This special issue is fully dedicated to the topic of azoospermia and contains the seminal
work of renowned scientists and clinicians from seven countries on three continents. In …

Previous studies have shown that Sox3 is expressed in nascent neuroprogenitor cells and is
functionally required in mammals for development of the dorsal telencephalon and …

Background Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy lacking
valid prognostic biomarkers. As a member of the High Mobility Group domain-containing …

Busulfan and cyclophosphamide (B/C)-treated mice exhibited a marked increase in
apoptosis and a concomitant decrease in the ovarian weight. Histological and RT-PCR …

Animals inhabiting cryptic environments are often subjected to morphological stasis due to
the lack of obvious agents driving selection, and hence chemical cues may be important …

Several endocrine‐disrupting chemicals with estrogenic activity can affect sexual
development and reproduction in aquatic wildlife. The occurrence of oocytes in the testis …

The transcription factor SOX3 is widely expressed in early vertebrate brain development. In
humans, duplication of SOX3 and polyalanine expansions at its C‐terminus may cause …