Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

Liposomes are delivery systems that have been used to formulate a vast variety of
therapeutic and imaging agents for the past several decades. They have significant …

The pH of solid tumors is acidic due to increased fermentative metabolism and poor
perfusion. It has been hypothesized that acid pH promotes local invasive growth and …

Malignant tumors remain a major health burden throughout the world and effective
therapeutic strategies are urgently needed. Cancer nanotechnology, as an integrated …

The aim of our study was to prepare multifunctional, biocompatible nanoparticles for site-
specific drug delivery. Hydrophilic nanoparticles with surface-adorned amine, carboxyl, or …

In vivo 31P MRS demonstrates that human melanoma xenografts in immunosuppressed
mice treated with lonidamine (LND, 100 mg/kg intraperitoneally) exhibit a decrease in …

Polymeric micelle can be targeted to tumor site by passive and active mechanism. Some
inherent properties of polymeric micelle such as size in nanorange, stability in plasma …

Mitotic chromosomal instability (CIN) plays important roles in tumor progression, but what
causes CIN is incompletely understood. In general, tumor CIN arises from abnormal mitosis …

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl
resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance …

Inspite of demanding research that has been undertaken for cancer treatment, cancer is a
major cause of mortality. Available conventional treatment options of solid tumor are …