Scope Resveratrol (RSV) has been proposed to prevent tumor growth; nevertheless, these
preventive effects are controversial since RSV pharmacokinetics studies show a low …

Little is known about the active positioning of transcripts outside of embryogenesis or highly
polarized cells. We show here that a specific G1 cyclin transcript is highly clustered in the …

Background Current models of cell-cycle control, based on classic studies of fused cells,
predict that nuclei in a shared cytoplasm respond to the same CDK activities to undergo …

Abnormal expression of cyclin-dependent kinase 2 (CDK2)/cyclin-E is detected in colorectal,
ovarian, breast and prostate cancers. The study of CDK2 with a bound inhibitor revealed …

Studies have demonstrated that regulation of GDNF on male germline stem cells (mGSCs)
mainly through Ras/Erk1/2, Src family kinase and PI3K/Akt signaling pathways, but the …

The ability of cells to copy their DNA allows them to transmit their genetic information to their
progeny. In such, this central biological process preserves the instructions that direct the …

En viktig faktor som kan føre til kreftutvikling er genomisk ustabilitet. Genomisk ustabilitet kan
være forårsaket av flere faktorer, blant annet økt forekomst av dobbeltrådbrudd, eller at …

The nucleus is a highly compartmentalized structure. One of the most prominent nuclear
compartments is the nucleolus. The nucleus and nucleolus share many structural and …

Transient, repetitive occlusion stimulates coronary collateral growth (CCG) in normal
animals and healthy humans. In normal, healthy animal models, vascular smooth muscle …

Classic studies demonstrated that when cells in different cell cycle phases are fused, nuclei
cohabiting in a common cytoplasm synchronize their division cycles. Cytoplasmic factors …