There is extensive bi-directional communication between the brain and the immune system
in both health and disease. In recent years, the role of an altered immune system in the …

There is compelling evidence to support an aetiological role for inflammation, oxidative and
nitrosative stress (O&NS), and mitochondrial dysfunction in the pathophysiology of major …

BACKGROUND: We conducted a meta-analysis of studies comparing cytokine
concentrations between patients with bipolar disorder (BD) and healthy control subjects …

Chronic inflammation and oxidative stress have been implicated in the pathophysiology of
Major Depressive Disorder (MDD), as well as in a number of chronic medical conditions …

Accumulating evidence suggests that inflammation may play a role in the pathophysiology of
major depressive disorder (MDD). Antidepressants, including selective serotonin reuptake …

Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-
derived neurotrophic factor (BDNF) signaling mechanisms as important in depression …

The frequently observed co-occurrence of depressive disorders and inflammatory diseases
suggests a close connection between the nervous and the immune systems. Increased pro …

There is a definite correlation between cardiovascular diseases and depressive disorders.
Nevertheless, many aspects of this association have yet to be fully elucidated. Up to half of …

Thiazolidinediones have shown beneficial effects in short-term treatment of depression.
However, it is unclear whether the antidepressant efficacy of these agents is related to their …

Rational Autism is associated with activation of the inflammatory response system. Objective
This study aims to assess the efficacy of a cyclooxygenase-2 inhibitor, celecoxib, as …