Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes
research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes …

The endocrine and exocrine cells in the adult pancreas are not static, but can change their
differentiation state in response to injury or stress. This concept of cells in flux means that …

While regional heterogeneity in islet distribution has been well studied in rodents, less is
known about human pancreatic histology. To fill gaps in our understanding, regional …

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β
cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that …

Aim To characterise changes in pancreatic beta cell mass during the development of
diabetes in untreated male C57BLKS/J db/db mice. Methods Blood samples were collected …

Aim: The aim of this study was to clarify the change in β-cell mass in Japanese obese
individuals. Methods: We obtained the pancreas at autopsy from 39 lean and 33 obese …

Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult
human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of …

Despite years of research in the field of type 1 diabetes, patients with the disease remain
without a therapeutic agent that can alter the underlying immune response in a clinically …

3. Ashcroft FM, Rorsman P. Diabetes mellitus and the beta cell: the last ten years. Cell
(2012) 148 (6): 1160–71. doi: 10.1016/j. cell. 2012.02. 010 4. Saisho Y, Butler AE, Manesso …

Aims/hypothesis In this study, we used an immunodeficient mouse model to explore, in vivo,
the longitudinal adaptation of human islets to an obesogenic environment. Methods Non …