Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

In adult articular cartilage, the extracellular matrix is maintained by a balance between the
degradation and the synthesis of matrix components. Chondrocytes that sparsely reside in …

Isoorientin (ISO)(CAS RN: 4261-42-1) is a flavonoid compound that can be extracted from
several plant species, such as Phyllostachys pubescens, Patrinia, and Drosophyllum …

Nitric oxide (NO) is one of the most important mediators of chondrocyte apoptosis, which is a
notable feature of cartilage degeneration. While apoptosis of chondrocytes is induced by …

Abstract Resveratrol (trans-3, 4'-trihydroxystillbene), a naturally occurring polyphenolic
antioxidant found in grapes and red wine, elicits diverse biochemical responses and …

Articular cartilage is an avascular tissue with poor regenerative capacity following injury, a
contributing factor to joint degenerative disease. Cell‐based therapies for cartilage tissue …

Our previous study reported that the saponin-rich fraction from Clematis chinensis Osbeck
roots (SFC) could effectively alleviate experimental osteoarthritis induced by monosodium …

背景: p38 丝裂原活化蛋白激酶信号转导通路属于丝裂原活化蛋白激酶家族成员,
在骨关节炎的发生发展中发挥重要作用. 目的: 对骨关节炎病理进程中p38 丝裂原活化蛋白激酶 …

Cartilage defects can be addressed with replacement strategies such as autologous
chondrocyte implantation (ACI). Expansion of autologous chondrocytes in vitro is an …

ETHNOPHARMACOLOGICAL RELEVANCE: Fuyuan Decoction (FYD) is an empirical
formula of treating Bi Zheng in traditional Chinese medicine (TCM). Despite the fact that the …