Metabolic changes in cells that participate in inflammation, such as activated macrophages
and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and …

The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy
that appears to have arisen at an early stage during eukaryotic evolution. In 2001 it was …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Short-chain fatty acids (SCFAs) have been shown to promote intestinal barrier function, but
their protective effects against ethanol-induced intestinal injury and underlying mechanisms …

Sirtuins are NAD+-dependent protein deacetylases that connect metabolism and cellular
homeostasis. Here we show that the nuclear Sirtuin SIRT7 targets PAF53, a subunit of RNA …

Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of
the upper airway. The basic structural and functional properties of respiratory muscles are …

An epidemic of metabolic disorders such as obesity and diabetes is rising dramatically.
Using natural products as potential preventive and therapeutic interventions for these …

The serine/threonine kinase LKB1 is a master kinase involved in cellular responses such as
energy metabolism, cell polarity and cell growth. LKB1 regulates these crucial cellular …

Key points• NAD is a substrate for sirtuins (SIRTs), which regulate gene transcription in
response to specific metabolic stresses.• Nicotinamide phosphoribosyl transferase (Nampt) …

Glucagon-like peptide-1 (GLP-1), an effective therapeutic agent for the treatment of diabetes,
has been proven to protect pancreatic beta cells through many pathways. Recent evidence …