Microfluidic platforms for mechanobiology

WJ Polacheck, R Li, SGM Uzel, RD Kamm - Lab on a Chip, 2013 - pubs.rsc.org
Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …

[HTML][HTML] Microfluidic devices for cell cultivation and proliferation

M Tehranirokh, AZ Kouzani, PS Francis, JR Kanwar - Biomicrofluidics, 2013 - pubs.aip.org
Microfluidic technology provides precise, controlled-environment, cost-effective, compact,
integrated, and high-throughput microsystems that are promising substitutes for …

Advances in microfluidics-based experimental methods for neuroscience research

JW Park, HJ Kim, MW Kang, NL Jeon - Lab on a Chip, 2013 - pubs.rsc.org
The application of microfluidics to neuroscience applications has always appealed to
neuroscientists because of the capability to control the cellular microenvironment in both a …

Exploring the mesenchymal stem cell niche using high throughput screening

SR Ghaemi, FJ Harding, B Delalat, S Gronthos… - Biomaterials, 2013 - Elsevier
In the field of stem cell technology, future advancements rely on the effective isolation, scale-
up and maintenance of specific stem cell populations and robust procedures for their …

Superimposed topographic and chemical cues synergistically guide neurite outgrowth

A Kundu, L Micholt, S Friedrich, DR Rand, C Bartic… - Lab on a Chip, 2013 - pubs.rsc.org
Guidance of neuronal extensions is a complex process essential for linking neurons into
complex functional networks underlying the workings of the neural system. Decades of …

Microfluidic investigation of bdnf‐enhanced neural stem cell chemotaxis in cxcl12 gradients

H Xu, SC Heilshorn - Small, 2013 - Wiley Online Library
In vivo studies have suggested that gradients of CXCL12 (aka stromal cell‐derived factor 1α)
may be critical for neural stem cell (NSC) migration during brain development and neural …

Microfluidic systems for studying neurotransmitters and neurotransmission

CA Croushore, JV Sweedler - Lab on a Chip, 2013 - pubs.rsc.org
Neurotransmitters and neuromodulators are molecules within the nervous system that play
key roles in cell-to-cell communication. Upon stimulation, neurons release these signaling …

Simultaneous generation of gradients with gradually changed slope in a microfluidic device for quantifying axon response

RR Xiao, WJ Zeng, YT Li, W Zou, L Wang… - Analytical …, 2013 - ACS Publications
Over the past decades, various microfluidic devices have been developed to investigate the
role of the molecular gradient in axonal development; however, there are very few devices …

Surface engineering the cellular microenvironment via patterning and gradients

AM Ross, J Lahann - Journal of Polymer Science Part B …, 2013 - Wiley Online Library
Cell organization, proliferation, and differentiation are impacted by diverse cues present in
the cellular microenvironment. As a result, the surface of a material plays an important role in …

A microfluidic device mimicking acinar concentration gradients across the liver acinus

MC Shih, SH Tseng, YS Weng, IM Chu, CH Liu - Biomedical microdevices, 2013 - Springer
The acinus-mimicking microfluidic chip, which simulates the in vivo condition of the liver,
was developed and reported in this paper. The gradient microenvironment of the liver acinus …