A pharmacokinetic standard for babies and adults
N Holford, YA Heo, B Anderson - Journal of pharmaceutical sciences, 2013 - Elsevier
The pharmacokinetic behavior of medicines used in humans follows largely predictable
patterns across the human age range from premature babies to elderly adults. Most of the …
patterns across the human age range from premature babies to elderly adults. Most of the …
Vancomycin continuous infusion in neonates: dosing optimisation and therapeutic drug monitoring
W Zhao, E Lopez, V Biran, X Durrmeyer… - Archives of disease in …, 2013 - adc.bmj.com
Objective Because pharmacokinetic data are limited, continuous infusions of vancomycin in
neonates are administered using different dosing regimens. The aim of this work was to …
neonates are administered using different dosing regimens. The aim of this work was to …
External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings
W Zhao, F Kaguelidou, V Biran, D Zhang… - British journal of …, 2013 - Wiley Online Library
Aims Vancomycin is one of the most evaluated antibiotics in neonates using modeling and
simulation approaches. However no clear consensus on optimal dosing has been achieved …
simulation approaches. However no clear consensus on optimal dosing has been achieved …
Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia
RA Shellhaas, CM Ng, CH Dillon… - Pediatric Critical Care …, 2013 - journals.lww.com
Objective: Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with
hypoxic ischemic encephalopathy are treated with therapeutic hypothermia, and about 40 …
hypoxic ischemic encephalopathy are treated with therapeutic hypothermia, and about 40 …
Amikacin maturation model as a marker of renal maturation to predict glomerular filtration rate and vancomycin clearance in neonates
W Zhao, V Biran, E Jacqz-Aigrain - Clinical pharmacokinetics, 2013 - Springer
Abstract Background and Objective Amikacin clearance has recently been proposed as a
marker of renal maturation in neonates. However, the predictive value of this marker is still …
marker of renal maturation in neonates. However, the predictive value of this marker is still …
目标浓度干预概况及研究进展
凌静， 焦正， 钟明康 - 中国药学杂志, 2013 - cqvip.com
目的综述目标浓度干预(target concentration intervention, TCI) 理论, 为临床个体化给药提供
依据. 方法查阅国内外相关文献和实践案例, 进行分析, 归纳, 总结及评述. 结果20 世纪60 年代 …
依据. 方法查阅国内外相关文献和实践案例, 进行分析, 归纳, 总结及评述. 结果20 世纪60 年代 …
[PDF][PDF] Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children
C Wang - 2013 - scholarlypublications …
Abstract Background and Objectives: The wide variability in pharmacokinetics of busulfan in
children is one factor influencing outcomes such as toxicity and event free survival. A meta …
children is one factor influencing outcomes such as toxicity and event free survival. A meta …
[PDF][PDF] Ravi sihtmärgi saavutamise tõenäosus vankomütsiini korduval manustamisel enneaegsetel vastsündinutel
K Oselin - core.ac.uk
Ravimiga organismis toimuvaid protsesse uurib farmakokineetika. Ravimi mõju uurimisega
organismi funktsioonidele tegeleb aga farmakodünaamika. Arvutusintensiivsete meetodite …
organismi funktsioonidele tegeleb aga farmakodünaamika. Arvutusintensiivsete meetodite …