Cadmium and cellular signaling cascades: interactions between cell death and survival pathways
F Thévenod, WK Lee - Archives of toxicology, 2013 - Springer
Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …
The UPR in atherosclerosis
AX Zhou, I Tabas - Seminars in immunopathology, 2013 - Springer
Multiple systemic factors and local stressors in the arterial wall can disturb the functions of
endoplasmic reticulum (ER), causing ER stress in endothelial cells (ECs), smooth muscle …
endoplasmic reticulum (ER), causing ER stress in endothelial cells (ECs), smooth muscle …
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
W B'chir, AC Maurin, V Carraro, J Averous… - Nucleic acids …, 2013 - academic.oup.com
In response to different environmental stresses, eIF2α phosphorylation represses global
translation coincident with preferential translation of ATF4, a master regulator controlling the …
translation coincident with preferential translation of ATF4, a master regulator controlling the …
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
BF Teske, ME Fusakio, D Zhou, J Shan… - Molecular biology of …, 2013 - Am Soc Cell Biol
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2,
triggering repression of global protein synthesis coincident with preferential translation of …
triggering repression of global protein synthesis coincident with preferential translation of …
Mesenchymal stem cells and endothelial progenitor cells decrease renal injury in experimental swine renal artery stenosis through different mechanisms
XY Zhu, V Urbieta-Caceres, JD Krier, SC Textor… - Stem …, 2013 - academic.oup.com
Endothelial progenitor cells (EPC) and mesenchymal stem cells (MSC) augment tissue
repair but possess slightly different properties. How the cellular phenotype affects the …
repair but possess slightly different properties. How the cellular phenotype affects the …
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver
MR Chikka, DDZ McCabe, HM Tyra… - Journal of biological …, 2013 - ASBMB
The unfolded protein response (UPR) senses stress in the endoplasmic reticulum (ER) and
initiates signal transduction cascades that culminate in changes to gene regulation. Long …
initiates signal transduction cascades that culminate in changes to gene regulation. Long …
A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux
Endoplasmic reticulum (ER) stress-induced responses are associated with the loss of insulin-
producing β-cells in type 2 diabetes mellitus. β-Cell survival during ER stress is believed to …
producing β-cells in type 2 diabetes mellitus. β-Cell survival during ER stress is believed to …
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences
AM Arensdorf, D Diedrichs, DT Rutkowski - Frontiers in genetics, 2013 - frontiersin.org
The mammalian unfolded protein response (UPR) is propagated by three ER-resident
transmembrane proteins, each of which initiates a signaling cascade that ultimately …
transmembrane proteins, each of which initiates a signaling cascade that ultimately …
ER stress and effects of DHA as an ER stress inhibitor
The endoplasmic reticulum (ER) functions in the synthesis, folding, modification, and
transport of newly synthesized transmembrane and secretory proteins. The ER also has …
transport of newly synthesized transmembrane and secretory proteins. The ER also has …
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model
V Scaiewicz, A Nahmias, RT Chung, T Mueller… - PLoS …, 2013 - journals.plos.org
Background and Aims C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the
integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated …
integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated …