Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human …

Glycaemic control, reduction of blood pressure using agents that block the renin–
angiotensin system and control of dyslipidaemia are the major strategies used in the clinical …

The glucose transporter GLUT4 plays a central role in maintaining body glucose
homeostasis. On insulin stimulation, GLUT4-containing vesicles fuse with the plasma …

The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and
plays a vital role in whole body glucose homeostasis. In the absence of insulin, only~ 1% of …

The vesicle fusion reaction in regulated exocytosis requires the concerted action of soluble
N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) core fusion engine …

Glucosensing nodose ganglia neurons mediate the effects of hyperglycemia on
gastrointestinal motility. We hypothesized that the glucose-sensing mechanisms in the …

Insulin increases cellular glucose uptake and metabolism in the postprandial state by
acutely stimulating the translocation of the Glut4 glucose transporter from intracellular …

The insulin-regulated trafficking of the facilitative glucose transporter GLUT4 in human fat
and muscle cells and the nitrogen-regulated trafficking of the general amino acid permease …

During exercise, phosphorylase kinase (PhK) is the key regulatory enzyme responsible for
maintaining glycogenolytic flux to sustain muscle contraction. The absence of PhK in …