OBJECTIVE It is of vital importance to elucidate the triggering factors of obesity and type 2
diabetes to improve patient care. Bariatric surgery has been shown to prevent and even cure …

Dexmedetomidine has been reported to reduce mortality in septic rats. This study was
designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung …

DCs orchestrate immune responses to infectious pathogens and disturbances in tissue
integrity. Equipped with C-type lectins, DCs can respond to environmental changes in …

Natural killer (NK) cells have been shown to play a regulatory role in sepsis. According to
the current view, NK cells become activated via macrophages or dendritic cells primed by …

Background Recruitment of macrophage precursors to the adventitia plays a key role in the
pathogenesis of abdominal aortic aneurysms (AAA s), but molecular mechanisms remain …

Background Chronic arthritis is a common feature of juvenile idiopathic arthritis (JIA) and
systemic lupus erythematosus (SLE). It was subsequently discovered that Toll-like receptors …

Poly-γ-glutamic acid (γ-PGA) is an anionic polypeptide secreted by Bacillus sp. that has
been shown to activate immune cells through interactions with toll-like receptor 4 (TLR4) …

The innate immune response to bacterial infection is mediated through Toll-like receptors
(TLRs), which trigger tightly regulated signaling cascades through transcription factors …

RP105 is a member of the toll-like receptor family of proteins that transmits an activation
signal in B cells, playing a role in regulation of B cell growth and death; in macrophages and …

Progressive HIV infection is characterized by profound enterocyte damage, microbial
translocation and chronic immune activation. We aimed to test whether High Mobility Group …