With lymphoid tissue anatomy different than mammals, and diverse adaptations to all
aquatic environments, fish constitute a fascinating group of vertebrate to study the biology of …

The human antibody repertoire is one of the most important defenses against infectious
disease, and the development of vaccines has enabled the conferral of targeted protection …

Annual influenza vaccinations aim to protect against seasonal infections, and vaccine strain
compositions are updated every year. This protection is based on antibodies that are …

Teleost fish are among the most ancient vertebrates possessing an adaptive immune system
with B and T lymphocytes that produce memory responses to pathogens. Most bony fish …

One of the hallmarks of the adaptive immune system is the specificity of B and T cell
receptors. Thanks to somatic recombination, a large repertoire of receptors can be …

Upon infection, B-lymphocytes expressing antibodies specific for the intruding pathogen
develop clonal responses triggered by pathogen recognition via the B-cell receptor. The …

T cell repertoire diversity is generated in part by recombination of variable (V), diversity (D),
and joining (J) segments in the T cell receptor β (TCR) locus. T cell clonal frequency …

In the decade since the human genome sequence was declared complete, the development
of next generation sequencing (NGS) or “deep” sequencing to deliver cost-effective genomic …

High-throughput measurement of gene-expression and immune receptor repertoires have
recently become powerful tools in the study of adaptive immune response. However, despite …

The vast diversity of antibody repertoires is largely attributed to heavy chain (VH)
recombination of variable (V), diversity (D) and joining (J) gene segments. We used 454 …