Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

A large number of cis-regulatory sequences have been annotated in the human genome,,
but defining their target genes remains a challenge. One strategy is to identify the long …

Understanding the topological configurations of chromatin may reveal valuable insights into
how the genome and epigenome act in concert to control cell fate during development …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …

In multicellular organisms, transcription regulation is one of the central mechanisms
modelling lineage differentiation and cell-fate determination. Transcription requires dynamic …

In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …

Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory
elements and local chromatin context on gene expression. However, so far such reporter …

Advances in genome sequencing have progressed at a rapid pace, with increased
throughput accompanied by plunging costs. But these advances go far beyond faster and …