Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors

LB Travis, WD Wahnefried, JM Allan… - Nature reviews Clinical …, 2013 - nature.com
Second and higher-order malignancies now comprise about 18% of all incident cancers in
the USA, superseding first primary cancers of the breast, lung, and prostate. The occurrence …

[HTML][HTML] Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk

S Braunstein, JL Nakamura - Frontiers in oncology, 2013 - frontiersin.org
One of the most significant effects of radiation therapy on normal tissues is mutagenesis,
which is the basis for radiation-induced malignancies. Radiation-induced malignancies are …

[HTML][HTML] Solid tumors after chemotherapy or surgery for testicular nonseminoma: a population-based study

C Fung, SD Fossa, MT Milano… - Journal of clinical …, 2013 - ncbi.nlm.nih.gov
Purpose Increased risks of solid tumors after older radiotherapy strategies for testicular
cancer (TC) are well established. Few population-based studies, however, focus on solid …

Immunogenic cell death in radiation therapy

L Galluzzi, O Kepp, G Kroemer - Oncoimmunology, 2013 - Taylor & Francis
In a recent issue of Cell Death and Differentiation, Ko and colleagues investigated how the
genetic inhibition of autophagy would impact on the response of human and murine lung …

The risk of childhood leukaemia following exposure to ionising radiation—a review

R Wakeford - Journal of Radiological Protection, 2013 - iopscience.iop.org
Since the early years of follow-up of the Japanese atomic-bomb survivors, it has been
apparent that childhood leukaemia has a particular sensitivity to induction by ionising …

Trial watch: anticancer radioimmunotherapy

E Vacchelli, I Vitale, E Tartour, A Eggermont… - …, 2013 - Taylor & Francis
Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …

Outcomes in stage I testicular seminoma: a population‐based study of 9193 patients

CJ Beard, LB Travis, MH Chen, ND Arvold… - Cancer, 2013 - Wiley Online Library
BACKGROUND Few studies have quantified temporal patterns of cause‐specific mortality in
contemporary cohorts of men with early‐stage seminoma. Given that several management …

Imaging effects of radiation therapy in the abdomen and pelvis: evaluating “innocent bystander” tissues

KE Maturen, MU Feng, AP Wasnik, SF Azar… - Radiographics, 2013 - pubs.rsna.org
Accurate interpretation of posttherapeutic images obtained in radiation oncology patients
requires familiarity with modern radiation therapy techniques and their expected effects on …

Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment

J Bonilla-Velez, EA Mroz, RJ Hammon… - … Clinics of North …, 2013 - oto.theclinics.com
Within the recent epidemic of oropharyngeal squamous cell carcinoma (OPSCC), 1 human
papillomavirus (HPV) has been found to play a pivotal role in defining a subset of patients …

Cardiac toxicity in cancer survivors

DJ Lenihan, S Oliva, EJ Chow, D Cardinale - Cancer, 2013 - Wiley Online Library
Cardiac disease is a major concern for cancer survivors, and this can be manifested as
cardiac dysfunction from myocardial damage, valvular disease, atherosclerosis, and/or …