The gut microbiota—masters of host development and physiology

F Sommer, F Bäckhed - Nature reviews microbiology, 2013 - nature.com
Establishing and maintaining beneficial interactions between the host and its associated
microbiota are key requirements for host health. Although the gut microbiota has previously …

The role of cytokines in inflammatory bone loss

PPC Souza, UH Lerner - Immunological investigations, 2013 - Taylor & Francis
Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as
rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is …

Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts

J Zupan, M Jeras, J Marc - Biochemia medica, 2013 - hrcak.srce.hr
Sažetak Bone and immune system are functionally interconnected. Immune and bone cells
derive from same progenitors in the bone marrow, they share a common microenvironment …

Dynamic visualization of RANKL and Th17-mediated osteoclast function

J Kikuta, Y Wada, T Kowada, Z Wang… - The Journal of …, 2013 - Am Soc Clin Investig
Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear
macrophage/monocyte-lineage hematopoietic precursor cells. Although previous studies …

The interplay between the bone and the immune system

G Mori, PD′ Amelio, R Faccio… - Journal of Immunology …, 2013 - Wiley Online Library
In the last two decades, numerous scientists have highlighted the interactions between bone
and immune cells as well as their overlapping regulatory mechanisms. For example …

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

BF Boyce - Journal of Bone and Mineral Research, 2013 - academic.oup.com
Osteoclasts are multinucleated myeloid lineage cells formed in response to macrophage
colony‐stimulating factor (M‐CSF) and receptor activator of NF‐κB ligand (RANKL) by fusion …

Th17 cells and IL-17 a—focus on immunopathogenesis and immunotherapeutics

WB van den Berg, IB McInnes - Seminars in arthritis and rheumatism, 2013 - Elsevier
abstract Importance Accumulating evidence suggests that IL-17 A has broad pathogenic
roles in multiple autoimmune and immune-mediated inflammatory diseases, including …

Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis

G Azizi, F Jadidi‐Niaragh… - International journal of …, 2013 - Wiley Online Library
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the
sequestration of various leukocyte subpopulations within both the developing pannus and …

Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone

C Sima, M Glogauer - Periodontology 2000, 2013 - Wiley Online Library
Chronic and aggressive periodontal diseases are characterized by the failure to resolve
local inflammation against periodontopathogenic bacteria in the subgingival biofilm …

Levels of circulating Th17 cells and regulatory T cells in ankylosing spondylitis patients with an inadequate response to anti− TNF-α therapy

L Xueyi, C Lina, W Zhenbiao, H Qing, L Qiang… - Journal of clinical …, 2013 - Springer
Purpose To investigate the effects of TNF-α blockage on levels of circulating Th17, Treg and
their related cytokines in ankylosing spondylitis (AS) patients with different response to anti …