Purpose: Gliomas are the most frequently occurring primary malignancies in the brain, and
glioblastoma is the most aggressive of these tumors. Protein kinase CK2 is composed of two …

Multiple myeloma (MM) is an incurable plasma cell malignancy, which causes a significant
morbidity due to organ damage and bone tissue destruction. In recent years, novel drugs …

CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on
bortezomib-regulated cellular pathways. In the present study, we investigated CK2 …

Protein kinase CK 2 is frequently elevated in a variety of human cancers. The Notch1
signalling pathway has been implicated in stem cell maintenance and its aberrant activation …

Background The involvement of protein kinase CK2 in sustaining cancer cell survival could
have implications also in the resistance to conventional and unconventional therapies …

Relapsed and refractory lymphoid and myeloid malignancies are often characterized by
progressive resistance to standard chemotherapy as well as poor long-term outcomes …

Protein kinase CK2 comprises two catalytic subunits (42 kDa α and 38 kDa α′) linked
through two regulatory subunits (28 kDa β) existing as αα′ β2 or α2β2 or α′ 2β2 …

Pyrazolo [4, 3-b] indole derivatives have been designed as novel CK2 inhibitor compounds
based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 …

Protein kinase CK2—more precisely its catalytic subunit CK2α—is one of 518 protein
kinases of the human kinome (Manning et al., 2002). Like all protein kinases, it catalyzes the …

CK2, probably the most pleiotropic protein kinase (Salvi et al., 2009), phosphorylates so
many proteins so it can be considered virtually involved in all cellular processes, such as …